TABLE 1.

Stress response genes are affected by aerobic fermentation but are attenuated in respiration conditions^a

Genec	ORF description	Ratioc
		Aero/ Stat	Resp/ Stat
ahpC	Alkyl hydroperoxide reductase	6	3
ahpF	Alkyl hydroperoxide reductase	6	2
gshR†	Glutathione reductase	8	4
hslB	HU-like DNA-binding protein	9	4
noxE	Major cytoplasmic NADH oxidase	15	2
osmC†	Osmotically inducible protein	15	7
pmsX	Peptide methionine sulfoxide reductase	12	5
qor	Quinone oxidoreductase	7	2
sodA	Superoxide dismutase	6	3
ybjA†	Peptide methionine sulfoxide reductase	9	4
yfiE†	Organic hydroperoxide resistance protein; OsmC homolog	11	5
yhjA	Similar to B. subtilis stress protein CsbD	11	3
ymgH	Similar to E. faecalis Gls24 stress protein	4	2
ymgK	Aldo-keto reductase involved in detoxification	14	5
ynfC	lactoyl glutathione lyase; serine-rich	14	5
yahB	UspA-like protein	6	2
yjaB	UspA-like protein	8	3
yobA	UspA-like protein	5	2
nifJ†	Pyruvate ferredoxin oxidoreductase	-16	-8
ypbB	Similar to Mg and Co transporter	-4	-2

^aGenes related to stress response and showing differences greater than ∼2-fold in aerobic fermentation compared to respiration growth are presented. Signal ratios of >4 of aerobic versus static fermentation were noted. Aero/Stat indicates the ratio of signal expression of aeration versus static (both fermentation) growth conditions. Resp/Stat indicates the ratio of signal expression of respiration versus static growth conditions. Functions are from KEGG annotations of L. lactis strain IL1403 (http://www.genome.jp/kegg/genes.html).

b †, Potential disulfide bonds are present in open reading frames (ORFs).

^cNegative values indicate downregulation.