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The hydrogenotrophic methanogenic pathway. See reference 3 for a full description of methanogenesis. The Hmd-Mtd cycle is boxed. Abbreviations: CoB, coenzyme B; CoM, coenzyme M; F420, coenzyme F420; Fd, ferredoxin; Frc, cysteine-containing F420-reducing hydrogenase; Fru, selenocysteine-containing F420-reducing hydrogenase; Mer, methylenetetrahydromethanopterin reductase; MFR, methanofuran.
