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. 2008 Apr 16;82(13):6251–6258. doi: 10.1128/JVI.00163-08

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FIG. 5. — Histological and immunohistochemical characterization of IRF-4 in CNS lymphomas. (A) Hematoxylin and eosin staining of a CNS lymphoma demonstrated the perivascular concentric accumulation of neoplastic cells. (B) Immunohistochemistry for the pan-B-cell marker CD20 highlighted the neoplastic lymphocytes in the Virchow-Robin space and confirmed their B-cell origin. (C) The EBV LMP-1 was robustly expressed in the cytoplasm of neoplastic lymphocytes in both the perivascular space and the brain parenchyma. (D) The expression of IRF-4 was detected in numerous neoplastic lymphocytes.