TABLE 3.
Factors associated with mutations in NS5A-PKRBD, NS5A-ISDR, and NS5A-V3a
| Region and mutations | Age (yr)
|
Sex
|
Genotype
|
Viral load (IU/ml)
|
||||
|---|---|---|---|---|---|---|---|---|
| ≤40 (n = 30) | >40 (n = 30) | Male (n = 34) | Female (n = 26) | 1a (n = 13) | 1b (n = 47) | ≤600,000 (n = 12) | >600,000 (n = 48) | |
| PKRBD | ||||||||
| ≤4 | 19 (63) | 22 (73) | 17 (50) | 24 (92)d | 9 (69) | 32 (68) | 3 (25) | 38 (79) |
| ≤4 | 11 (37) | 8 (27) | 17 (50) | 2 (8) | 4 (31) | 15 (32) | 9 (75)g | 10 (21) |
| ISDR | ||||||||
| Without | 7 (23) | 15 (50) | 9 (27) | 13 (50) | 2 (15) | 20 (43) | 1 (8) | 21 (44) |
| With | 23 (77)b | 15 (50) | 25 (73)c | 13 (50) | 11 (85)f | 27 (57) | 11 (92)h | 27 (56) |
| V3 | ||||||||
| ≤5 | 19 (63) | 20 (67) | 17 (50) | 22 (85)e | 10 (77) | 29 (62) | 8 (67) | 31 (65) |
| ≤5 | 11 (37) | 10 (35) | 17 (50) | 4 (15) | 3 (23) | 18 (38) | 4 (33) | 17 (35) |
a
Data are expressed as numbers of patients with percentages in parentheses. Comparisons between groups were made by the χ2 or Fisher exact test for the categorical variables. A P value of <0.05 was considered statistically significant.
b
Statistically significant difference (P = 0.03).
c
Statistically significant difference (P = 0.05).
d
Statistically significant difference (P = 0.0001).
e
Statistically significant difference (P = 0.0001).
f
Statistically significant difference (P = 0.06).
g
Statistically significant difference (P = 0.006).
h
Statistically significant difference (P = 0.021).