TABLE 5.
Effects of ssDNAs on IFN-γ production by PBMCs isolated from human donorsa
| ODN | Concn (μM) | IFN-γ production (pg/ml) of PBMCs treated with:
|
||||
|---|---|---|---|---|---|---|
| Mock (n = 6)
|
Poly(I-C) (n = 6)
|
|||||
| Range | Mean | Range | Mean | % | ||
| Mock | 1-27 | 14 | 1,160-6,674 | 4,214 | 100 | |
| 2006 | 1 | ND | 11-1,842 | 579 | 14 | |
| 5 | 1-42 | 25 | 6-56 | 31 | 1 | |
| 2006c | 1 | ND | 1-195 | 72 | 2 | |
| 5 | 1-56 | 25 | 13-95 | 44 | 1 | |
| 2216 | 1 | ND | 82-2,681 | 1,447 | 34 | |
| 5 | 4-64 | 38 | 55-631 | 287 | 7 | |
| 2216c | 1 | ND | 56-4,483 | 1,887 | 45 | |
| 5 | 16-135 | 53 | 25-3,266 | 1,278 | 30 | |
a
Effects of two concentrations of ssDNAs on IFN-γ production from six donors. Poly(I-C) was used at 5 μg/ml. ND, not done.