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. 2008 May 5;28(13):4261–4274. doi: 10.1128/MCB.02252-07

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FIG. 8. — Genetic interaction map linking crp-1 and the UPR proximal sensors. (A to C) The percentage of progeny arrested in the L1 stage of development was plotted against different concentrations of TM (2 or 5 μg/ml) for N2 (A), pek-1⁻^/⁻ (B), and atf-6⁻^/⁻ (C) animals subjected or not to crp-1 RNAi. (D) The percentage of progeny arrested in the L1 stage of development was plotted against different concentrations of TM (2 or 5 μg/ml) for crp-1⁻^/⁻ animals subjected to xbp-1 RNAi. (E) Schematic representation of CDC-48-dependent pathways proposed to explain the implication of CRP-1, HIM-6, and ATM-1 in the regulation of ER homeostasis during stress condition through DNA remodeling/transcriptional processes.