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. 1999 Dec 7;96(25):14541–14546. doi: 10.1073/pnas.96.25.14541

Figure 3.

Figure 3

z-VAD prevents apoptosis in thymocytes and splenocytes during sepsis. Female ND4 mice (Harlan) underwent CLP or sham surgery, as described in Methods. One hour after surgery, mice received z-VAD at 0.1, 1.0, or 10.0 mg/kg body weight. Apoptosis was evaluated 18–22 hr after CLP or sham surgery by annexin V labeling and flow cytometry of isolated thymocytes (Upper) or splenocytes (Lower), as described in Methods. Sham-operated mice and mice treated with 1.0 or 10.0 mg/kg body weight z-VAD were significantly different from untreated CLP mice; *, P < 0.05. The number of mice per group is indicated in parentheses.