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. 1999 Dec 7;96(25):14541–14546. doi: 10.1073/pnas.96.25.14541

Figure 4.

Figure 4

Overexpression of Bcl-2 improves survival in sepsis. Generation of the Bcl-2-Ig transgenic mice has been described previously (17) (see Methods). Bcl-2 overexpressor mice and age- and sex-matched B6C3F1 mice underwent CLP. One hour after CLP, mice received metromidazole and ceftriazone as antibiotic coverage (see Methods for details). Antibiotics were repeated every 12 hr for 48 hr, and survival was improved in Bcl-2 overexpressors vs. B6C3F1 mice; *, P < 0.02. n = number of mice in each group.