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Atg5 is required for HIF-1-dependent regulation of mitochondrial mass and respiration in MEFs. WT and KO MEFs were transfected with siRNA directed against Atg5 (siAtg5) or a control siRNA (siCTR) and cultured at 20 or 1% O2 for 48 h. Mitochondrial DNA content (A), mitochondrial mass (B), O2 consumption (C), and ATP levels (D) were measured. Mean values are shown (±S.E.). *, p < 0.05 by Student's t test compared with WT-siCTR at 20% O2;#, p < 0.05 compared with WT-siCTR at 1% O2.
