Table 5.

Breast and ovarian cancers occurring after the family was referred to the genetics centre.

	Number of women	Years f/u (Breast ca)	Cancers	Rate (%/Year)	Number of women	Years f/u (ovarian ca)	Cancers	Rate
BRCA1 Carriers	256	1522.33	65	4.27	403	2256.13	37	1.64
BRCA1 FDR unknown	341	1988.07	13	0.65	355	2049.42	6	0.29
BRCA1 Index	87	399.49	37	9.3	194	977.35	24	2.5
BRCA1 Carriers less index	159	1122.33	28	2.5	209	1278.78	13	1.01
BRCA2 Carriers	210	1210.41	61	5.0	363	2235.14	12	0.54
BRCA2 FDR unknown	324	2096.93	12	0.57	345	2187.04	4	0.19
BRCA2 Index	66	285.59	36	12.6	175	966.69	9	0.93
BRCA2 Carriers less index	144	924.82	25	2.7	363	1268.45	3	0.24

Censored if affected with relevant cancer prior to date of referral and at RRS, relevant cancer diagnosis, or date of last follow up.

The index case was used to identify the mutation. Women were censored at time of risk reducing surgery.