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Characterization of ‘pituitary signet-ring cells’ in Prop1 transgenic pituitary. H&E stain, immunostaining of GH, PRL, αGSU, TSHβ, LHβ, ACTH, Pit1 and ERα. All sections were counter-stained by methyl green or hematoxylin nuclear stain. Four cases of Prop1 Tg pituitaries reveal signet-ring hypertrophic gonadotropes. Arrow: pituitary signet-ring cells, white arrowhead: nuclei of signet-ring cells. Bars=50 µm.
