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. 2008 Jul 23;3(7):e2769. doi: 10.1371/journal.pone.0002769

Figure 1. Nod2 mediates susceptibility to Y. pseudotuberculosis infection in mice.

Figure 1

Nod2+/+ and Nod2−/− mice in the C57BL/6j and FVB/N backgrounds were orogastrically inoculated with 10 fold dilutions ranging from 6,5×105 to 6,5×109 CFU of Y. pseudotuberculosis pIB102 wild-type strain. Survival curves of mice, all different infection dose groups used for LD50 analysis confounded, are shown for the (a) C57BL/6j background and (b) for the FVB/N background. Nod2−/− mice died significantly later than Nod2+/+ control mice (p<0.01; Log-Rank test). (c) Nod2 mutated mice were infected with 1×109 CFU of YPIII(pIB102) and died significantly later than Nod2 wild type littermate controls (p<0.001; Log-Rank test). (d) No survival difference was seen after intraperitoneal infection of Nod2−/− and Nod+/+ mice with 5×104 CFU of YPIII(pIB102) (P = 0.61; Log-Rank test).