Figure 11.

Modeled flux behavior when inhibiting pathway enzymes. The predicted flux when varying the enzyme activity was obtained using the kinetic model for Entamoeba histolytica glycolysis [142]. In this case, 100% enzyme activity is the enzyme activity present in amebal extracts, and 100% flux is the ethanol flux displayed by amoebae incubated with glucose. PPi-PFK, PPi-dependent phosphofructokinase; PPDK, pyruvate phosphate dikinase; PGAM, 2,3 bisphosphoglycerate independent 3-phosphoglycerate mutase.