NADH-CoQ-oxidoreductase
(Site 1 of energy conservation or Complex I of respiratory chain) |
0.15 |
Heart
(0.5 mM pyr + 0.2 μM Ca2+) |
Rotenone |
Noncompetitive
tightly bound |
[93]
|
0.26 |
Heart
(10 mM pyr + 10 mM mal) |
[95] |
0.31 |
Kidney
(0.5 mM pyr + 0.2 μM Ca2+) |
[93] |
0.06 |
Kidney (10 mM pyr + 10 mM mal) |
[95] |
0.06–0.10 |
Brain (0.05 mM pyr + 0.4 μM Ca2+) |
[91]
|
0.25 |
Brain (10 mM pyr + 10 mM mal) |
[95]
|
0 |
Tumor (10 mM glut + 3 mM mal) |
[96]
|
0.27 |
Liver (10 mM pyr + 10 mM mal) |
[95] |
0.13 |
Skeletal muscle (10 mM pyr + 10 mM mal) |
[95] |
|
CoQ.cytochrome
c oxidoreductase (Site 2 of energy conservation or Complex III of respiratory
chain) |
0.01 |
Heart |
Antimycin |
Noncompetitive
tightly bound |
[93]
|
0.19 |
Heart |
[95]
|
0.02 |
Kidney |
[95]
|
0.05–0.11 |
Brain |
[91]
|
0.02 |
Brain |
[95]
|
0 |
Tumor |
[96]
|
0.43 |
Liver (5 mM Succ + 1 μM Ca2+) |
[94] |
0.07 |
Liver |
[95] |
0.22 |
Skeletal muscle |
[95] |
|
Cytochrome
c oxidase (Site 3 of energy conservation or Complex IV of respiratory chain) |
0.11 |
Heart |
Cyanide
or azide |
Noncompetitive
simple |
[93] |
0.13 |
Heart |
[95] |
0.04 |
Kidney |
[95] |
0.02–0.07 |
Brain |
[91] |
0.02 |
Brain |
[95] |
0.04 |
Tumor |
[96] |
0.23 |
Liver |
[94] |
0.03 |
Liver |
[95] |
0.20 |
Skeletal
muscle |
[95] |
|
ATP/ADP
transporter (adenine-nucleotides or ATP/ADP transporter, carrier or exchanger) |
0.24 |
Heart |
Carboxy-atractyloside (CAT) |
Noncompetitive
tightly bound |
[93] |
0.04 |
Heart |
[95]
|
0 |
Kidney |
[93] |
0.07 |
Kidney |
[95] |
0.08 |
Brain
|
[91] |
0.08 |
Brain
|
[95] |
0.60–0.70 |
Tumor |
[96] |
0.48 |
Liver
|
[93] |
0.01 |
Liver
|
[93] |
0.37 |
Skeletal
muscle (10 mM Glut + 3 mM mal) |
[97] |
0.08 |
Skeletal
muscle |
[95] |
|
ATP synthase |
0.34 |
Heart |
Oligomycin |
Noncompetitive tightly bound |
[93] |
0.12 |
Heart |
[95] |
0.32 |
Kidney |
[93] |
0.27 |
Kidney |
[95] |
0.09–0.20 |
Brain |
[91] |
0.26 |
Brain |
[95] |
0.28 |
Tumor |
[96] |
0.05 |
Liver |
[94] |
0.20 |
Liver |
[95] |
0.10 |
Skeletal muscle |
[97] |
0.10 |
Skeletal muscle |
[95] |
|
Pi transporter |
0.15 |
Heart |
Mersalyl |
Noncompetitive simple |
[93] |
0.14 |
Heart |
[95] |
0.43 |
Kidney |
[93] |
0.28 |
Kidney |
[95] |
0.13 |
Brain |
[91] |
0.26 |
Brain |
[95] |
0 |
Tumor |
[96] |
0.05–0.12 |
Liver |
[94] |
0.26 |
Liver |
[95] |
0.15 |
Skeletal muscle |
[97] |
0.08 |
Skeletal muscle |
[95] |
|
Pyruvate transporter |
0.15 |
Heart |
α-cyano-4-hydroxy-cinnamate |
Noncompetitive simple |
[95] |
0.03 |
Kidney |
[95] |
0.08 |
Brain |
[91] |
0.26 |
Brain |
[95] |
0.21 |
Liver |
[95] |
0.20 |
Skeletal muscle |
[95] |
|
Dicarboxylates transporter |
0.05–0.14 |
Liver |
Malate or butyl-malonate |
Competitive simple |
[94] |
|
External ATPase |
0.40 |
Skeletal muscle |
Purified ATPase addition |
|
[94] |