Table 1.
Influence of beta-defensin copy number on relative risk of psoriasis.
Counts are given in the table, together with the relative risk of psoriasis given the observed copy number, with a relative risk of 1.00 representing the population mean risk (2%).
| Copy number |
Dutch Controls |
Dutch Patients |
German Controls |
German Patients |
Combined Controls |
Combined Patients |
Copy number |
Population Frequency % |
Relative Risk* |
95% CI Relative Risk |
|---|---|---|---|---|---|---|---|---|---|---|
| 2 | 8 | 2 | 12 | 4 | 20 | 6 | 2 | 3.5 | 0.31 | 0.12-0.77 |
| 3 | 54 | 16 | 69 | 46 | 123 | 62 | 3 | 21.3 | 0.51 | 0.37-0.71 |
| 4 | 115 | 79 | 131 | 124 | 246 | 203 | 4 | 42.6 | 0.84 | 0.67-1.05 |
| 5 | 73 | 55 | 68 | 94 | 141 | 149 | 5 | 24.4 | 1.08 | 0.83-1.40 |
| 6 | 20 | 21 | 13 | 39 | 33 | 60 | 6 or more | 8.1 | 1.69 | 1.16-2.48 |
| 7 | 2 | 4 | 6 | 7 | 8 | 11 | ||||
| 8 | 0 | 2 | 5 | 4 | 5 | 6 | ||||
| 9 | 0 | 0 | 1 | 0 | 1 | 0 | ||||
| 12 | 0 | 0 | 0 | 1 | 0 | 1 | ||||
| sum | 272 | 179 | 305 | 319 | 577 | 498 |
*
Relative risk values were calculated after pooling copy numbers of 6 or more into a single category. Bold type indicates a two-tailed significant difference from a relative risk of 1.00 at the 5% level. Population frequency shows an estimate of diploid copy number frequencies in native Northern Europeans deduced from the “combined controls” column.