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. 2008 Jul 14;182(1):77–88. doi: 10.1083/jcb.200804062

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© 2008 Woolner et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Myo10 localizes to mitotic spindle poles in X. laevis embryos. (a) Confocal micrographs of interphase and mitotic cells in the epithelium of X. laevis embryos double stained for α-tubulin (red) and Myo10 (green). During interphase and prophase, Myo10 localizes to the nucleus. From metaphase, Myo10 can be seen localized as a band close to the pole, a position it maintains through anaphase and telophase. Throughout the cell cycle, Myo10 is also found at the cell cortex (see Fig. S1, available at http://www.jcb.org/cgi/content/full/jcb.200804062/DC1) but is less obvious in these images, as fluorescent levels were reduced due to the high intensity of the nuclear staining. (b) Confocal images of an anaphase spindle double stained for γ-tubulin (red) and Myo10 (green) showing that Myo10 localizes to a region just inside the spindle pole marker γ-tubulin. (c) Confocal micrographs of spindles immunostained for α-tubulin, Myo10 (red), and TPX2 (green) showing that Myo10 and TPX2 display significant colocalization.