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. 2008 Jul 10;118(8):2733–2746. doi: 10.1172/JCI32381

Figure 5. Intimal thickening after cuff placement in response to Ang II infusion in Lr11–/– mice.

Figure 5

(A) I/M ratios of femoral arteries in Lr11+/+ or Lr11–/– mice after cuff placement with saline or Ang II infusion (1 μg/kg/min for 28 days) are presented as mean ± SD (n = 15). *P < 0.05. (B) mRNA levels of NMHCII-B and LRP1 in injured arteries. Total RNA isolated from the intima or the media of Lr11+/+ or Lr11–/– mice was reverse transcribed into cDNA and subjected to real-time PCR analysis using specific primers for NMHCII-B and LRP1, respectively. The amounts of amplified products are expressed relative to the amounts of β-actin transcript, and the ratio of mRNA expression levels of intima and media are presented as mean ± SD (n = 3). *P < 0.05.