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Time course of fasting in A-ZIP/F-1 mice. Female A-ZIP/F-1 and littermate controls (wild type; 4–6 weeks old, n = 5 per group) were fasted for 0, 2, 4, 6, 12, and 24 hr (see Methods). Body weight (A) and plasma glucose (B), insulin (C), triglyceride (D), FFA (E), and blood urea nitrogen (BUN) (F) concentrations were measured. At 24 hr of fasting, the A-ZIP/F-1 mice were different from the wild-type mice (P < 0.01) for all parameters shown.
