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. 1999 Dec 7;96(25):14623–14628. doi: 10.1073/pnas.96.25.14623

Figure 5.

Figure 5

Leptin prevents fasting-induced torpor in ob/ob but not A-ZIP/F-1 mice. Tb was measured in 12- to 13-week-old male ob/ob and C57BL/6J control (A) and A-ZIP/F-1 and littermate FVB/N control (B) mice. Leptin pumps were inserted (day 0) and mice regained normal circadian Tb rhythms by day 3. The 24-hr fast was begun on day 5. Data are hourly averages ± SEM (■, ob/ob + saline; □, ob/ob + leptin; ●, wild-type + saline; ○, wild-type + leptin; ▾, A-ZIP/F-1 + saline; ▿, A-ZIP/F-1 + leptin). The dash-dot line indicates ambient temperature and the black bar indicates lights out. One A-ZIP/F-1 + saline mouse died (at 12:30 p.m.), and three A-ZIP/F-1 + leptin mice died (at 9:30 a.m., 11:30 a.m., and 11:30 a.m.).