Figure 2.

Repeated but not a single exposure to restraint stress inhibits BK-induced plasma extravasation. (A) BK induces sustained plasma extravasation (●, n = 14). One exposure to restraint stress does not affect BK-induced plasma extravasation (■, n = 13), while four (♦, n = 12) or seven (▴, n = 14) daily exposures to restraint stress markedly inhibit it. (B) BK-induced plasma extravasation is markedly inhibited 1 (▴, n = 14) and 5 hr (▾, n = 5) after the seventh daily exposure to restraint stress and returns to control levels (●, n = 14) 24 hr after the seventh daily exposure to restraint stress (✠, n = 5).