Figure 3.

Stress-induced inhibition of BK-induced knee joint plasma extravasation is mediated by the HPA axis. (A) Seven-day restraint stress-induced inhibition of plasma extravasation (▴, n = 14) was completely blocked in animals that had been adrenalectomized 1 wk prior to receiving restraint stress (▵, n = 11). BK-induced plasma extravasation was not significantly different in these animals compared with control animals that had been adrenalectomized but not subjected to restraint stress (○, n = 15). (B) Seven-day restraint stress-induced inhibition of plasma extravasation (▴, n = 14) was not affected in animals that had undergone adrenal medullae denervation 1 wk prior to receiving restraint stress (▵, n = 10). A curve depicting BK-induced plasma extravasation in control rats that had undergone adrenal denervation but had not received restraint stress (○, n = 6) is included for comparison.