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. 2008 Jun 16;105(24):8440–8445. doi: 10.1073/pnas.0803096105

Table 1.

Inhibition of STa-stimulated cGMP accumulation in T84 cells

Compound Inhibition, % Formula Compound Inhibition, % Formula
Ia graphic file with name zpq01808044800g1.jpg IVa graphic file with name zpq01808044800g7.jpg
19 ± 4 26 ± 7
Ib graphic file with name zpq01808044800g2.jpg Va graphic file with name zpq01808044800g8.jpg
7 ± 1 29 ± 6
IIa (BPIPP) graphic file with name zpq01808044800g3.jpg VIa graphic file with name zpq01808044800g9.jpg
86 ± 4 42 ± 5
IIb graphic file with name zpq01808044800g4.jpg VII graphic file with name zpq0180804480g10.jpg
2 ± 1 38 ± 6
IIIa graphic file with name zpq01808044800g5.jpg VIII graphic file with name zpq0180804480g11.jpg
83 ± 16 22 ± 4
IIIb graphic file with name zpq01808044800g6.jpg IXa graphic file with name zpq0180804480g12.jpg
17 ± 2 56 ± 11

T84 cells were pretreated with the indicated compounds at 50 μM or vehicle (0.1% DMSO) and 1 mM 3-isobutyl-1-methylxanthine (IBMX) for 10 min and then treated with 100 nM STa for 10 min, and cGMP accumulation in the cells was measured. Accumulation of cGMP in the presence of vehicle was 221 ± 34 pmol of cGMP per mg of protein. Data are mean ± SEM of six independent experiments assayed in duplicate.