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Thermodynamic parameters for hTDG and hTDGcat binding to abasic DNA
| Enzyme | DNA | ΔH, kcal/mol | TΔS, kcal/mol | ΔG, kcal/mol | N |
|---|---|---|---|---|---|
| hTDGcat | THF28 | 34 ± 1 | 43 ± 1 | −8.9 ± 0.1 | 0.58 ± 0.04 |
| hTDGcat | THF15 | 14.6 ± 0.1 | 24.2 ± 0.2 | −9.6 ± 0.1 | 0.81 ± 0.05 |
| hTDG | THF28 | 29.5 ± 0.9 | 39.9 ± 0.9 | −10.23 ± 0.03 | 0.52 ± 0.03 |
| hTDG | THF15 | 17.3 ± 0.4 | 24.8 ± 0.7 | −10.34 ± 0.06 | 0.50 ± 0.02 |
Values represent mean ± SD determined from at least three independent experiments.
