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. 2008 Jun 23;105(26):9017–9022. doi: 10.1073/pnas.0710445105

Fig. 1.

Fig. 1.

Nod expression in RA synovial tissue. (A) mRNA expression of Nod1 or Nod2 in RA and OA synovial tissue samples expressed as relative expression to the houskeeping gene GAPDH (2−delta Ct value × 1,000). (B and C) Cytokine production of RA synovial tissue after exposure to MDP, FK156, and LPS. (D) MDP-containing fragments in RA synovial tissue showed by immunohistochemical staining of paraffin sections using MoAb 2–4-5 (39). (E) Isotype control. Both synovial lining cells and endothelial cells contain MDP fragments. (D and E) ×200 magnification. (F) MDP staining of OA synovial tissue; note almost no staining. Isotype control. (F and G) ×100 magnification.