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. 2008 Jun 23;105(26):9017–9022. doi: 10.1073/pnas.0710445105

Fig. 2.

Fig. 2.

SCW-induced arthritis in Nod1 or Nod2 gene-deficient mice. (A) Joint swelling at days 1 and 2 after induction of SCW arthritis in wild-type, Nod1, Nod2, and TLR2 gene-deficient mice. The joint swelling (99mTechnetium uptake) is expressed as a right-left ratio, and a ratio >1.10 is indicated as inflammation. Joint swelling is strongly reduced in both Nod2 and TLR2 gene-deficient mice. At least seven mice per group were used, and the repeated experiment showed similar results. (B and C) Cytokine concentrations determined 4 h after induction of SCW arthritis in patellae washouts. The cytokines were measured in 50 μl of patellae washout (n = 6 per group), using a multiplex bead array kit. *, P < 0.05, Mann–Whitney U test, compared with wild-type control.