Table 1.

Joint pathology in Nod1- or Nod2-deficient mice

	Influx of inflammatory cells		Proteoglycan depletion
	Joint cavity	Synovial tissue
WT*	1.3 ± 0.2	0.8 ± 0.2	0.7 ± 0.2
Nod1−/−	2.0 ± 0.3†	1.4 ± 0.03†	1.6 ± 0.3†
Nod2−/−	0.5 ± 0.03†	0.3 ± 0.2‡	0.3 ± 0.2‡

Histology was performed at day 2 of SCW arthritis. Cell influx of both joint cavity and synovial tissue was scored on a scale ranging from 0 to 3. Loss of cartilage matrix proteoglycans was determined on Safranin O-stained sections and scored a scale of 0–3.

*WT, C57Black/six mice.

^†P < 0.05, Mann–Whitney U test compared with wild-type mice.

^‡P < 0.001, Mann–Whitney U test compared with wild-type mice. At least seven mice per group were included, and the study was repeated once with similar results.