Skip to main content
. 2008 Jun 30;105(26):9070–9075. doi: 10.1073/pnas.0710181105

Fig. 1.

Fig. 1.

EtOH-induced sensitization is absent in CRF1 and CRF1 + 2 receptor KO, but not CRF2 KO mice. Total 15-min locomotor response (mean ± SEM) to 1.5 g/kg EtOH in KO and WT mice pretreated for 10 days with saline (S) or 2.5 g/kg EtOH (E). CRF1 (Top; n = 13–15 per group): *, different from saline-pretreated WT and EtOH-pretreated KO mice [simple main effect (SME) P < 0.01]; #, different from saline-pretreated WT mice (SME P < 0.05). CRF2 (Middle; n = 9–15 per group): *, main effect of EtOH pretreatment; no statistically significant difference in the magnitude of EtOH sensitization was found between genotypes. CRF1 + 2 (Bottom; n = 12–15 per group): *, different from saline-pretreated WT and EtOH-pretreated double-KO mice (SME P < 0.01); #, different from saline-pretreated WT mice (SME P < 0.05).