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. 2008 Jun 30;105(26):9070–9075. doi: 10.1073/pnas.0710181105

Fig. 3.

Fig. 3.

The CRF1 receptor antagonist, CP-154,526, inhibits the acquisition (Upper) and blocks the expression (Lower) of EtOH sensitization. Shown in the Upper is the time course for the locomotor response (mean ± SEM) to 1.5 g/kg EtOH in D2 mice treated for 10 days with saline (S) or 1.5 g/kg EtOH (E), 30 min after vehicle (V), 15 or 30 mg/kg CP-154,526 (CP15 and CP30, respectively); n = 10–15 per group. * indicates that CP30-E is different from V-E and CP15-E at the 5-min time point (SME P < 0.01). Shown in Lower is total distance traveled in 15 min (mean ± SEM) after 1.5 g/kg EtOH in D2 mice treated for 10 days with saline (S) or 1.5 g/kg EtOH (E), 30 min after vehicle (V) and then challenged with E, 30 min after V, 15 or 30 mg/kg CP-154,526 (CP15 and CP30 respectively); n = 12–14 per group. *, different from respective saline pretreated groups (SME P < 0.01); #, different from animals pretreated with E on days 1–10 and tested with V-E on day 11 (Newman–Keuls, P < 0.05).