Fig. 3.

Unaffected synaptic connections and basal synaptic transmission at thalamo-amygdala synapses. (A) Representative images of a principal neuron expressing shNL1 (Left). The dendritic region outlined with a dotted line was magnified to delineate spines (Right). (Scale bars: Left, 50 μm; Right, 10 μm.) (B) Summary histogram of spine densities (number of spines per 10 μm dendrite segment) for control and shNL1-infected neurons (P > 0.3 for both). (C) Sample traces of mEPSCs recorded from control and shNL1-infected neurons. (D) Cumulative amplitude (Upper) and interevent interval (Lower) plots of mEPSCs for control (n = 17) versus shNL1- (n = 20) infected neurons. Kolmogorov–Smirnov test was used for the comparison (P > 0.1 for both). (E) Summary histograms of mEPSC parameters. The mean peak amplitudes (P > 0.3) and the mean frequencies (P > 0.2) were not significantly different between two groups.