Figure 1.
Effect of chronic ethanol consumption on the maximal variation in mean arterial blood pressure (MAP) induced by i.v. injection of ET-1 (0.01, 0.025, 0.05 or 0.1 nmol kg−1) or IRL1620 (0.001, 0.01, 0.025, 0.05, 0.1, 0.25 or 1.0 nmol kg−1) in the anaesthetized rat. Each point represents the mean±s.e.mean of 6–11 independent experiments for the maximal depressor (a, c) and pressor (b, d) response induced by ET-1 or IRL1620. No depressor responses to IRL1620 were found in the dose range of 0.001–0.05 nmol kg−1 (only the doses of 0.01 nmol kg−1 and higher of IRL1620 are shown) (*P<0.05 compared with control group; Student's t-test).