Figure 3.
Effect of BQ123 (1 or 2.5 mg kg−1) on the maximal variation in mean arterial blood pressure (MAP) induced by i.v. injection of endothelin (ET)-1 (0.025 nmol kg−1) in anaesthetized control and ethanol-treated rats. Each point represents the mean±s.e.mean of 5–6 independent experiments for the maximal depressor (a) and pressor (b) response induced by ET-1 (*P<0.05 compared with control group; # compared with the respective group in the absence of BQ123; ANOVA followed by Bonferroni's comparison test).