Table 1.

Croton oil (CO)-treated mice: effect of i.p.-injected cannabidiol (CBD, 5 mg kg⁻¹) alone or in the presence of the CB₂ antagonist SR144528 (1 mg kg⁻¹), the opioid antagonist naloxone (2 mg kg⁻¹) or the α₂-adrenoceptor antagonist yohimbine (1 mg kg⁻¹) on intestinal transit in vivo

Treatment	Motility (geometric centre)
Control (no croton oil)	4.91±0.43
Croton oil (CO)	6.65±0.41#
CO+CBD	5.01±0.36*
CO+CBD+SR144528	4.99±0.38*
CO+CBD+naloxone	4.98±0.44*
CO+CBD+yohimbine	4.97±0.43*

^#P<0.05 vs control.

^*P<0.05 vs croton oil.

N=8–10 animals for each experimental group. Transit was expressed as the geometric centre (GC) of the distribution of a fluorescent marker along the small intestine. GC ranged from 1 (minimal motility) to 10 (maximal motility) (see Methods section).