Figure 2.

(Top)—Verhoeff-stained slices of rat lungs previously treated with saline (0.2 mL i.t.; left) or compound 48/80 (1 mg kg⁻¹ i.t.; right) and killed 24 h after either challenge. The black arrows denote the presence of oedema around the vessel (V) and the bronchi (B) following compound 48/80 treatment. (Bottom)—Perivascular oedema assessed from the left and right caudal lobes. Values (means±s.e.mean for four rats in each group) represent oedema percent. The oedema value 24 h after compound 48/80 (1 mg kg⁻¹ i.t.) treated rats was significantly greater than saline-treated animals (0.2 mL i.t.; ^***P<0.001; Student's t-test (two tailed)).