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. 2008 Jul 1;99(1):118–125. doi: 10.1038/sj.bjc.6604465

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Copyright © 2008 Cancer Research UK

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p53 knockdown in SkSC decreases sensitivity to etoposide and vincristine. (A) p53 knockdown was complete at the RNA (a) and protein levels (b) using siRNA. (B) p53 knockdown resulted in multiple less-uniform centrosomes (a), and about 30% of the cells had an abnormal >2 pericentrin signals per cell (b). (C) Cell numbers determined in p53 knockdown SkSC after a 72 h treatment with etoposide (a), vincristine (b), and TNP-470 (c). Cells were plated in triplicate and treated with each drug for 72 h before dispersing in trypsin and counting. ^*Results are statistically significant (P<0.05) by student's t-test.