Table 2.
Rate of claudin-3 and claudin-4 expression (absent/weak vs. high) and disease characteristics including type of histology, FIGO stage, and grade.
| Patients | Claudin-3 Positive IHC | Claudin-4 Positive IHC | ||||
|---|---|---|---|---|---|---|
| No. | Valid % | No. | Valid % | No. | Valid % | |
| Histology* | ||||||
| Endometrioid grade 1 | 52 | (18) | 19/48 | (40) | 1/47 | (2) |
| Endometrioid grade 2 | 58 | (20) | 20/54 | (37) | 4/51 | (7) |
| Endometrioid grade 3 | 40 | (14) | 14/36 | (39) | 7/31 | (18) |
| Clear cell | 25 | (9) | 14/23 | (61) | 10/23 | (44) |
| Serous papillary | 112 | (39) | 69/89 | (78) | 49/88 | (56) |
| FIGO Stage** | ||||||
| I | 146 | (51) | 55/123 | (45) | 21/125 | (17) |
| II | 9 | (3) | 4/8 | (50) | 0/8 | (0) |
| III | 52 | (18) | 26/48 | (54) | 14/49 | (29) |
| IV | 80 | (28) | 51/71 | (72) | 36/69 | (52) |
| Grade*** | ||||||
| 1 | 55 | (20) | 20/50 | (40) | 2/50 | (4) |
| 2 | 62 | (23) | 23/58 | (40) | 5/59 | (9) |
| 3 | 153 | (57) | 81/128 | (63) | 56/128 | (44) |
Unknown data: grade (n = 17), claudin-3 (n = 37), claudin-4 (n = 36).
*
Chi square test: P < 0.001 for both Claudin-3 and Claudin-4.
**
Chi square test: P = 0.004 for Claudin-3, and P < 0.001 for Claudin-4.
***
Chi square test: P = 0.002 for Claudin-3, and P < 0.001 for Claudin-4.