Table 3.
Adjusted circulating serum hormone levels in men by estrogen-related genotypes
| Gene | SNP | Genotype | No. | Estradiol
|
Testosterone
|
Estradiol to testosterone ratio
|
|||
|---|---|---|---|---|---|---|---|---|---|
| Median (25th-75th percentile) | P value | Median (25th-75th percentile) | P value | Median (25th-75th percentile) | P value | ||||
| CYP19A1 | rs700518 | G/G | 210 | 26.73 (25.76–28.14) | 0.005 | 5.51 (5.14–5.86) | 0.60 | 4.86 (4.47–5.26) | 0.006 |
| G/A | 305 | 27.44 (26.29–28.83) | 5.35 (5.05–5.73) | 5.06 (4.74–5.60) | |||||
| A/A | 161 | 30.35 (29.42–31.65) | 5.26 (4.99–5.65) | 5.61 (5.33–5.96) | |||||
| (TTTA)n | S/S | 190 | 26.32 (25.47–27.55) | 0.02 | 5.45 (5.18–5.82) | 0.51 | 4.78 (4.48–5.18) | 0.01 | |
| S/L | 331 | 27.79 (26.82–29.10) | 5.31 (5.04–5.63) | 5.19 (4.87–5.61) | |||||
| L/L | 167 | 29.55 (28.62–30.60) | 5.26 (5.01–5.67) | 5.47 (5.19–5.78) | |||||
| rs726547 | C/C | 713 | 27.22 (26.33–28.57) | 0.03 | 5.40 (5.12–5.78) | 0.01 | 5.01 (4.67–5.42) | 0.0005 | |
| C/T | 85 | 29.89 (28.75–31.75) | 5.14 (4.79–5.42) | 5.87 (5.44–6.36) | |||||
| ESR1 | (TA)n | L/L | 164 | 27.45 (26.69–28.71) | 0.74 | 5.41 (5.16–5.73) | 0.41 | 5.05 (4.73–5.36) | 0.75 |
| L/S | 338 | 28.34 (27.54–29.43) | 5.34 (5.05–5.70) | 5.25 (4.95–5.72) | |||||
| S/S | 164 | 27.53 (26.81–28.46) | 5.28 (4.99–5.60) | 5.09 (4.79–5.45) | |||||
| rs2077647 | T/T | 224 | 27.57 (26.74–28.55) | 0.41 | 5.26 (4.97–5.59) | 0.22 | 5.16 (4.84–5.52) | 0.21 | |
| T/C | 408 | 28.18 (27.31–29.49) | 5.38 (5.06–5.75) | 5.20 (4.88–5.65) | |||||
| C/C | 159 | 26.70 (25.75–27.98) | 5.46 (5.22–5.87) | 4.84 (4.52–5.22) | |||||
| rs2234693 | T/T | 246 | 27.80 (26.96–28.96) | 0.84 | 5.40 (5.08–5.76) | 0.54 | 5.07 (4.78–5.45) | 0.79 | |
| T/C | 400 | 27.50 (26.47–28.97) | 5.32 (5.07–5.65) | 5.15 (4.81–5.54) | |||||
| C/C | 160 | 27.18 (26.30–28.83) | 5.47 (5.22–5.95) | 4.97 (4.60–5.36) | |||||
| rs9340799 | A/A | 327 | 27.99 (27.07–29.16) | 0.81 | 5.32 (5.04–5.70) | 0.59 | 5.18 (4.89–5.52) | 0.69 | |
| A/G | 378 | 27.36 (26.40–28.90) | 5.43 (5.13–5.75) | 5.06 (4.72–5.48) | |||||
| G/G | 109 | 26.87 (26.19–28.50) | 5.44 (5.21–5.94) | 4.94 (4.51–5.32) | |||||
| rs1801132 | C/C | 468 | 27.47 (26.47–28.81) | 0.90 | 5.34 (5.07–5.68) | 0.87 | 5.13 (4.78–5.48) | 0.76 | |
| C/G | 269 | 27.58 (26.74–28.88) | 5.41 (5.12–5.80) | 5.08 (4.79–5.46) | |||||
| G/G | 45 | 27.85 (27.30–29.43) | 5.39 (5.15–5.80) | 5.05 (4.69–5.49) | |||||
| (CA)n | S/S | 242 | 27.34 (26.60–28.55) | 0.70 | 5.27 (4.94–5.59) | 0.33 | 5.15 (4.79–5.58) | 0.93 | |
| S/L | 297 | 28.26 (27.47–29.32) | 5.44 (5.19–5.84) | 5.11 (4.82–5.53) | |||||
| L/L | 79 | 28.01 (27.06–29.10) | 5.23 (4.98–5.63) | 5.27 (4.96–5.71) | |||||
| ESR2 | rs1256059 | C/C | 225 | 28.06 (27.28–29.43) | 0.56 | 5.32 (5.08–5.70) | 0.18 | 5.23 (4.94–5.64) | 0.20 |
| C/T | 402 | 27.45 (26.53–28.59) | 5.34 (5.02–5.66) | 5.09 (4.76–5.51) | |||||
| T/T | 168 | 27.01 (26.15–28.17) | 5.58 (5.31–6.01) | 4.86 (4.52–5.22) | |||||
| (CA)n | S/S | 515 | 27.22 (26.41–28.46) | 0.20 | 5.42 (5.10–5.76) | 0.49 | 5.01 (4.71–5.45) | 0.60 | |
| S/L | 274 | 28.32 (27.38–29.73) | 5.33 (5.08–5.69) | 5.23 (4.95–5.58) | |||||
| L/L | 27 | 24.97 (24.13–25.71) | 5.20 (4.95–5.58) | 4.80 (4.55–5.02) | |||||
| rs1256031 | T/T | 213 | 28.05 (27.24–29.59) | 0.73 | 5.31 (5.07–5.69) | 0.09 | 5.19 (4.89–5.56) | 0.33 | |
| T/C | 403 | 27.37 (26.39–28.53) | 5.33 (5.02–5.65) | 5.13 (4.79–5.52) | |||||
| C/C | 194 | 27.43 (26.53–28.65) | 5.61 (5.32–6.05) | 4.90 (4.54–5.30) | |||||
Adjusted for age, weight, smoking, and alcohol consumption.