Table 1.
Associations of CYP3A7*1C with androgen levels
| Overalla
|
Controls
|
PCOS
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| NC | C | P | NC | C | P | NC | C | P | |
| DHEAS (ng/ml) | 1575.5 (1596.0) | 1027.0 (794.8) | 0.002b | 966.0 (706.0) | 845.5 (622.0) | 0.27 | 2141.0 (1757.8) | 1386.0 (960.3) | 0.0006b |
| Total T (ng/dl) | 69.0 (40.0) | 60.5 (25.0) | 0.36 | 41.0 (27.3) | 49.5 (32.5) | 0.62 | 80.0 (33.5) | 70.5 (29.0) | 0.046 |
| Free T (pg/ml) | 0.70 (0.52) | 0.46 (0.46) | 0.083 | 0.36 (0.27) | 0.37 (0.18) | 0.74 | 0.85 (0.46) | 0.80 (0.39) | 0.31 |
Data are median (interquartile range). T, Testosterone; NC, noncarriers; C, carriers of CYP3A7*1C.
a
In the analysis of the whole cohort, PCOS status was also adjusted for, along with age and BMI.
b
Significant P < 0.025.