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. 2008 Apr 3;149(7):3427–3434. doi: 10.1210/en.2008-0207

Figure 1.

Figure 1

The CS-17 Fab retains inverse agonist activity. CHO cells stably expressing the wild-type TSHR were incubated for 1 h at 37 C in the absence or presence of the indicated concentrations of CS-17 mAb or Fab. Each bar represents the mean ± sd of duplicate wells. The boxed gray area indicates the mean cAMP value in control, untransfected CHO cells. Extension of the bars beyond the boxed area represents TSHR constitutive activity. The experiment shown is representative of two experiments in the present study. Additional experiments in which CS-17 Fab inhibit TSHR constitutive activity in HEK293 cells are shown in Fig. 5.