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. 2008 Apr 10;149(7):3346–3354. doi: 10.1210/en.2007-0945

Figure 1.

Figure 1

Loss of Stat3 from Agrp/Npy neurons resulted in increased adiposity. A, CON mice (n = 6–22) and DEL littermates (n = 5–21) were weighed weekly for 20 wk. Two-way ANOVA indicated statistically significant effects of both time and genotype (P < 0.001) and a significant interaction between these factors (P < 0.05). B, Body weights of 12-wk-old males (n = 5/group) and females (n = 8–11/group) showed DEL mice to weigh more (P < 0.001) than littermate controls. Twelve-week-old males (n = 5/group) were analyzed for body fat (C and D) and lean mass (E) as described in Materials and Methods. F, Weights of epididymal fat pads from 20-wk-old fed or fasted (48 h) mice (n = 4 mice/group). Statistical analysis by two-way ANOVA indicates significant effects of genotype (P < 0.01) and fasting (P < 0.05) but no interaction effect. Values are means ± sem. *, Statistical significance at P < 0.05; ***, P < 0.001 by two-tailed unpaired t test.