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. 2008 Mar 27;149(7):3500–3511. doi: 10.1210/en.2007-1508

Figure 8.

Figure 8

Activation of PKA increased GnRH-1 neuronal activity. Recording from a single cell shows that Sp-cAMPS stimulates calcium oscillations (left panel). The number of peaks per minute was modified by Sp-cAMPS in comparison with SFM (N = 2, n = 19; *, P < 0.05, Student’s paired t test). The lower panel shows changes in intracellular calcium in 14 cells simultaneously recorded during the experimental paradigm (BIC-SpcAMPs-SFM). Each row represents changes in intracellular calcium in a single cell, and dots mark significant calcium peaks. Lines indicate the time for drug application as shown on the single-cell trace.