Figure 4.

Intra-tumor treatment with OncSyn and OncdSyn viruses. (a) Balb/c mice were implanted subcutaneously in the interscapular area with 1 × 10⁵ viable 4T1 cells. Tumors were measured using a digital caliper at defined time intervals prior and after treatment (x axis). Tumors were injected with either OncSyn, OncdSyn viruses, or PBS when tumors reached approximately 80–90 mm³ in volume. Tumor volumes were measured prior to (negative values on the x axis) and after the injections. "0" on X axis represents the day of the first injection. The tumor volumes were determined from the formula: volume = (length × width × height)/2. Arrows indicate the days when therapy was administered. The error bars represent means ± 2 standard errors. (b) Tumors were excised at 42 days post implantation and visually examined. Panel shows representative tumors from virus and PBS treated animals.