Table 4.
Enriched pathways of estrogen regulated genes in human and rat
| Gene Set | Rat T1* | Human T1* |
| Cholesterol_Biosynthesis // Genmapp | 6.55 | 3.91 |
| Cellular Lipid Metabolism // GO:0044255 | 2.21 | 3.67 |
| Mitotic Cell Cycle // GO:0000278 | 2.8 | 3.14 |
| Cysteine Protease Inhibitor Activity // GO:0004869 | 2.94 | 3.02 |
| Small Protein Conjugating Enzyme Activity // GO:0008639 | 2.34 | 2.85 |
| Epidermis Development // GO:0008544 | 5.44 | 2.65 |
| Steroid Metabolism // GO:0008202 | 3.23 | 2.65 |
| Ubiquitin Conjugating Enzyme Activity // GO:0004840 | 2.3 | 2.55 |
| Tgf_Beta_Signaling_Pathway: Biocarta | -3.09 | -2.54 |
| Complement_Activation_Classical | -2.29 | -2.57 |
| Chr3Q13: Cytogenetic Band | -2.36 | -2.6 |
| Complement_Activation_Classical // GenMAPP | -2.43 | -2.63 |
| TGF_Beta_Signaling_Pathway // GenMAPP | -2.93 | -2.64 |
| Matrix_Metalloproteinases // GenMAPP | -3.06 | -2.65 |
| Complement Activation, Classical Pathway // GO:0006958 | -2.28 | -2.67 |
| Cell Differentiation // GO:0030154 | -2.39 | -2.71 |
| GLUT_UP: Peng_at_al_2002 | -3.26 | -2.73 |
| chr1q24: Cytogenetic band | -2.87 | -2.89 |
| Matrix_Metalloproteinases: BioCarta | -2.52 | -2.95 |
| RAP_UP: Peng_at_al_2002 | -3.46 | -2.99 |
| Locomotory Behavior // GO:0007626 | -2.28 | -3.14 |
| Transmembrane Receptor Protein Tyrosine Kinase Activity // GO:0004714 | -2.66 | -3.16 |
| EMT_UP: Jechlinger_et_al_2003 | -3.18 | -3.21 |
| Specific Rna Polymerase Ii Transcription Factor Activity // GO:0003704 | -3.01 | -3.24 |
| RAR_UP: Manually Curated | -3.08 | -3.25 |
| Response To Wounding // GO:0009611 | -2.48 | -3.28 |
| Cell Motility // GO:0006928 | -2.73 | -3.29 |
| Locomotion // GO:0040011 | -2.7 | -3.33 |
| cell_adhesion | -2.32 | -3.34 |
| classic complement pathway | -2.77 | -3.34 |
| Vascular Endothelial Growth Factor Receptor Activity // GO:0005021 | -2.56 | -3.38 |
| Transmembrane Receptor Protein Kinase Activity // GO:0019199 | -3.09 | -3.48 |
| Immune Complement Pathway | -3.25 | -3.66 |
| STTTCRNTTT: IRF:Interferon regulatory factor | -3.55 | -3.7 |
| CR_IMMUNE_FUNCTION: PNAS_2009 | -3.29 | -3.72 |
| Response To Virus // GO:0009615 | -2.65 | -3.85 |
| Cell Adhesion // GO:0007155 | -5.01 | -4.05 |
| Humoral Defense Mechanism // GO:0016064 | -2.75 | -4.37 |
| Humoral Immune Response // GO:0006959 | -2.93 | -4.42 |
| Antigen Processing // GO:0030333 | -3.72 | -4.49 |
| morf1_34033_s_at_LILRB1: na | -3.27 | -4.66 |
| Antigen Presentation // GO:0019882 | -3.98 | -5.87 |
| Response To External Biotic Stimulus // GO:0043207 | -2.73 | -5.95 |
| Response To Pest, Pathogen Or Parasite // GO:0009613 | -2.87 | -6.21 |
| Immune Response // GO:0006955 | -3.61 | -6.49 |
T1* Score of differential expression (NT_k statistic as described in Tian et al[20].)