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. 2008 Jun 17;7:57. doi: 10.1186/1476-4598-7-57

Figure 1.

Figure 1

Diagram representing the rationale of CoMet. (A) The intracellular level of a metabolite X is predicted to be increased in cancer cells when enzymes that produce X are upregulated and/or enzymes that consume X are downregulated in cancer cells. (B) The intracellular level of a metabolite X is predicted to be decreased in cancer cells when enzymes that produce X are downregulated and/or enzymes that consume X are upregulated in cancer cells. See Material and Methods for a complete description of the rules.