Table 3.

Allele (a) and genotype (b) frequencies of the TLR4 gene variants in patients with Löfgren's syndrome, acute and chronic clinical forms of sarcoidosis. One patient selected randomly from families with two or more patients of the same phenotype was chosen for the case–control comparisons. Sixty-five sib-pair families included patients with acute and with chronic sarcoidosis and contributed to both subgroups; n, number of analysed individuals.

TLR-4 polymorphism	Allele	Löfgren's syndrome n = 152	Acute (incl. Löfgren's syndrome) n = 323	Chronic sarcoidosis n = 680	Acute and chronic sarcoidosis n = 938	Control subjects n = 537
(a)
c.-4036A > G	0	0	10	6	14	14
	A	220 (0·72)	453 (0·71)	981 (0·72)	1343 (0·72)	756 (0·71)
	G	84 (0·28)	183 (0·29)	373 (0·28)	519 (0·28)	304 (0·29)
c.94-837G > A	0	4	12	30	40	12
	A	78 (0·26)	150 (0·24)	346 (0·26)	464 (0·25)	282 (0·27)
	G	222 (0·74)	484 (0·76)	984 (0·74)	1372 (0·75)	780 (0·73)
Asp299Gly	0	2	6	8	14
	A	283 (0·94)	600 (0·94)	1267 (0·94)	1741 (0·94)	1013 (0·94)
	G	19 (0·06)	40 (0·06)	85 (0·06)	121 (0·06)	61 (0·06)
Thr399Ile	0	2	12	12	26	20
	T	23 (0·08)	43 (0·07)	91 (0·07)	128 (0·07)	62 (0·06)
	C	279 (0·92)	591 (0·93)	1257 (0·93)	1722 (0·93)	992 (0·94)
(b)
c.-4036 A > G	00	0	5	3	7	7
	AA	78 (0·51)	155 (0·49)	360 (0·53)	485 (0·52)	273 (0·51)
	AG	64 (0·42)	143 (0·45)	261 (0·39)	373 (0·40)	210 (0·40)
	GG	10 (0·07)	20 (0·06)	56 (0·08)	73 (0·08)	47 (0·09)
c.94–837G > A	00	2	6	15	20	6
	AA	8 (0·05)	14 (0·04)	47 (0·07)	56 (0·06)	42 (0·08)
	AG	62 (0·41)	122 (0·38)	252 (0·38)	352 (0·38)	198 (0·37)
	GG	80 (0·53)	181 (0·57)	366 (0·55)	510 (0·56)	291 (0·55)
Asp299Gly	00	1	3	4	7	0
	AA	132 (0·87)	282 (0·88)	592 (0·88)	813 (0·87)	479 (0·89)
	AG	19 (0·13)	36 (0·11)	83 (0·12)	115 (0·12)	55 (0·10)
	GG	0 (0·00)	2 (0·01)	1 (0·001)	3 (0·003)	3 (0·01)
Thr399Ile	00	1	6	6	13	10
	TT	1 (0·01)	3 (0·01)	1 (0·001)	5 (0·01)	3 (0·01)
	CT	21 (0·14)	37 (0·12)	89 (0·13)	118 (0·13)	56 (0·11)
	CC	129 (0·85)	277 (0·87)	584 (0·87)	802 (0·87)	468 (0·89)