Table 2.
Unstimulated T helper 1 (Th1)- and Th2-producing CD4+ and CD8+ T-cells from peripheral blood of ischaemic stroke patients and controls.
| Cytokine | Group | CD4+ T cells (%) | P-value* | CD8+ T cells (%) | P-value* |
|---|---|---|---|---|---|
| IFN-γ | MC | 0·06 ± 0·04 | n.s. | 0·09 ± 0·05 | n.s. |
| ISs- | 0·08 ± 0·04 | 0·11 ± 0·04 | |||
| ISs+ | 0·10 ± 0·05 | 0·09 ± 0·02 | |||
| IL-2 | MC | 0·18 ± 0·10 | n.s. | 0·17 ± 0·10 | n.s. |
| ISs- | 0·15 ± 0·09 | 0·18 ± 0·15 | |||
| ISs+ | 0·16 ± 0·09 | 0·17 ± 0·11 | |||
| IL-4 | MC | 0·09 ± 0·04 | n.s. | 0·08 ± 0·03 | n.s. |
| ISs- | 0·12 ± 0·06 | 0·16 ± 0·15 | |||
| ISs+ | 0·13 ± 0·07 | 0·17 ± 0·14 | |||
| IL-10 | MC | 0·27 ± 0·14 | n.s. | 0·43 ± 0·22 | n.s. |
| ISs- | 0·22 ± 0·19 | 0·34 ± 0·31 | |||
| ISs+ | 0·29 ± 0·29 | 0·29 ± 0·23 |
Whole blood was cultured for 5 h in plain medium in the presence of brefeldin A. The values of cytokine-producing cells were calculated as the percentage of CD4+ and CD8+ peripheral T cells. Data are expressed as mean ± standard deviation.
*
P-values refer to the comparison between the three study groups (MC, ISs -, ISs+) using one-way analysis of variance test. IL, interleukin; IFN, interferon; ISs-, ischaemic stroke patients not receiving statins (n = 17); ISs+, IS patients receiving statins (n = 6); MC, matched controls (n = 7); n.s., not statistically significant.