Table 3.
Induced T helper 1 (Th1) and Th2 cytokine-producing CD4+ and CD8+ T cells from peripheral blood of ischaemic stroke patients and controls, following mitogenic stimulation.
| Cytokine | Group | CD4+ T cells (%) | P-value* | CD8+ T cells (%) | P-value* |
|---|---|---|---|---|---|
| IFN-γ | MC | 29·10 ± 9·14 | n.s. | 63·97 ± 17·59 | n.s. |
| ISs- | 25·72 ± 10·59 | 64·79 ± 15·83 | |||
| ISs+ | 33·23 ± 9·29 | 68·16 ± 14·71 | |||
| IL-2 | MC | 63·77 ± 11·26 | n.s. | 21·50 ± 8·47 | n.s. |
| ISs- | 63·32 ± 12·34 | 20·07 ± 7·79 | |||
| ISs+ | 63·61 ± 10·93 | 24·64 ± 3·62 | |||
| IL-4 | MC | 0·23 ± 0·18 | 0·17 ± 0·10 | ||
| ISs- | 1·09 ± 0·95 | 0·027 | 0·90 ± 0·97 | n.s. | |
| ISs+ | 1·04 ± 0·39 | 0·028 | 1·33 ± 1·15 | 0·015 | |
| IL-10 | MC | 0·41 ± 0·21 | n.s. | 0·48 ± 0·28 | n.s. |
| ISs- | 0·37 ± 0·22 | 0·28 ± 0·20 | |||
| ISs+ | 0·56 ± 0·36 | 0·30 ± 0·11 |
Whole blood samples were cultured with phorbol 12-myristate13-acetate/ionomycin for 5 h in the presence of brefeldin A. The values of cytokine-producing cells were calculated as the percentage of CD4+ and CD8+ peripheral T cell populations. The data are expressed as mean ± standard deviation.
*
The post-hoc Tukey test was used to compare MC with ISs- and MC with ISs+. IL, interleukin; IFN, interferon; ISs-, ischaemic stroke patients not receiving statins (n = 17); ISs+, IS patients receiving statins (n = 6); MC, matched controls (n = 7); n.s., not statistically significant.