Table 2.
The frequency of genotypes and alleles of the 3′ untranslated region (1188A/C) polymorphism on interleukin (IL-12B) gene.
| Genotype | Allele | ||||
|---|---|---|---|---|---|
| AA (%) | AC (%) | CC (%) | A (%) | C (%) | |
| Exposed–uninfected | |||||
| n = 76 | 42 | 26 | 8* | 110 | 42† |
| (%) | 55·3 | 34·2 | 10·5 | 72·4 | 27·6 |
| HCV RNA positive | |||||
| n = 123 | 81 | 39 | 3 | 201 | 45 |
| (%) | 65·9 | 31·7 | 2·4 | 81·7 | 18·3 |
| HCV RNA negative | |||||
| n = 72 | 36 | 33 | 3 | 105 | 39 |
| (%) | 50 | 45·8 | 4·2 | 72·9 | 27·1 |
| Healthy controls | |||||
| n = 105 | 71 | 33 | 1 | 175 | 35 |
| (%) | 67·7 | 31·4 | 0·9 | 83·3 | 16·7 |
*
The CC genotype was significantly more frequent in exposed–uninfected cases compared with both hepatitis C virus (HCV) RNA-positive patients and controls [χ2 = 6·5, P = 0·04, odds ratio (OR) = 4·7 and χ2 = 9·3, P = 0·01, OR = 12 respectively].
†
The C allele was significantly more frequent in exposed–uninfected cases compared with HCV RNA-positive patients and controls (χ2 = 4·8, P = 0·03, OR = 1·7 and χ2 = 6·3, P = 0·02, OR = 1·9 respectively).