Figure 2. Kaplan-Meier survival plots of C57Bl/6J mice treated with lentiviral vectors.

Mice inoculated with ME7 prion strain were administered with either : (A) one unique injection of PBS or ΨGFP or ΨPrPQ167R at 35 days p.i.; (B) one unique injection of PBS or ΨGFP or ΨPrPQ167R at 105 days p.i.; (C) two injections of PBS or ΨGFP or ΨPrPQ167R at 80 and 95 days p.i., through a cannula implanted in the mice brain. Healthy mice were treated with ΨPrPQ167R at 80 and 95 days p.i.