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. 2008 Jul 23;3(7):e2742. doi: 10.1371/journal.pone.0002742

Figure 5. (A) Paradoxical heat sensation (PHS) to mild cold stimuli as elicited by alternating cold and warm stimulation (TSL).

Figure 5

PHS was a frequent finding in both hands in acute CRPS, and fully subsided in the chronic phase. Significance vs. controls: *** p<0.001; Significance vs. acute CRPS: +++ p<0.001; Significance vs. ipsilateral hand: (§) p<0.10, § p<0.05. Note: Significance marks that bridge symbols of ipsilateral and contralateral hands apply to both hands. (B) PHS-positive CRPS patients (PHS+) exhibited a significantly more pronounced cold hyperalgesia than PHS-negative CRPS patients (PHS−). In contrast, there was no such difference in heat hyperalgesia. Error bars show 1SEM.