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. 1998 Dec 8;95(25):14833–14838. doi: 10.1073/pnas.95.25.14833

Figure 3.

Figure 3

MAPK activity is required for neural induction by endogenous signals. (A) Ectoderm from embryos microinjected with 4 ng per embryo ΔMKP-1 or ΔP-MKP-1 mRNA was isolated at stage 10 and assayed for MAPK activity. Overexpression of MKP leads to a loss of MAPK activity. (B) Ectoderm from embryos overexpressing MKP-1 was isolated at stage 10 and recombined with involuted dorsal mesoderm from midgastrula embryos; recombinates were cultured until controls reached midneurulation (stage 15) and subjected to RT-PCR assays (n = 3).